Efficacy and safety of herbal medicines for idiopathic Parkinson's disease: A systematic review
Identifieur interne : 001310 ( Main/Exploration ); précédent : 001309; suivant : 001311Efficacy and safety of herbal medicines for idiopathic Parkinson's disease: A systematic review
Auteurs : Vincent Chung [Hong Kong] ; Liang Liu [Hong Kong] ; Zhaoxiang Bian [Hong Kong] ; Zhongzhen Zhao [Hong Kong] ; Wai Leuk Fong [Hong Kong] ; Wan Fung Kum [Hong Kong] ; Jing Gao [Hong Kong] ; Min Li [Hong Kong]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-10.
English descriptors
Abstract
The objective of this study is to assess the efficacy and safety of herbal medicines (HMs), as a monotherapy or adjunct therapy, compared to placebo or conventional approaches in the treatment of idiopathic Parkinson's disease (PD). We conducted a systematic review of randomized controlled trials from both conventional and alternative medicine sources. Outcome measures were overall improvement, quality of life, reduction of levodopa dose, and adverse events. Nine studies were included, each testing a different HM. Six of the trials had limited internal validity due to major flaws in design, including the lack of proper randomization; insufficient blinding; unclear inclusive criteria in terms of diagnostic criteria, baseline staging, and duration of disease; lack of proper sample size calculation; and insufficient data analysis. Imbalances in gender and ethnicity among the patients in the included trials were observed. No major adverse events emerged, and no specific pattern was detected from the trials describing such data. In addition to major methodological defects, heterogeneity in (1) HM tested, (2) control treatment, and (3) outcome measure hindered in‐depth data analysis and synthesis. Current evidence is insufficient to evaluate the efficacy and safety of various HMs. Further studies with improved trial design and reporting, with assessment on cost‐effectiveness, quality of life, and qualitative data are warranted. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.21008
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-10">2006-10</date><biblScope unit="volume">21</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1709">1709</biblScope><biblScope unit="page" to="1715">1715</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">638D6DE1C7F0732A0DD959CC328CC84994E2BBEC</idno><idno type="DOI">10.1002/mds.21008</idno><idno type="ArticleID">MDS21008</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>herbal medicines</term><term>systemic review</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study is to assess the efficacy and safety of herbal medicines (HMs), as a monotherapy or adjunct therapy, compared to placebo or conventional approaches in the treatment of idiopathic Parkinson's disease (PD). We conducted a systematic review of randomized controlled trials from both conventional and alternative medicine sources. Outcome measures were overall improvement, quality of life, reduction of levodopa dose, and adverse events. Nine studies were included, each testing a different HM. Six of the trials had limited internal validity due to major flaws in design, including the lack of proper randomization; insufficient blinding; unclear inclusive criteria in terms of diagnostic criteria, baseline staging, and duration of disease; lack of proper sample size calculation; and insufficient data analysis. Imbalances in gender and ethnicity among the patients in the included trials were observed. No major adverse events emerged, and no specific pattern was detected from the trials describing such data. In addition to major methodological defects, heterogeneity in (1) HM tested, (2) control treatment, and (3) outcome measure hindered in‐depth data analysis and synthesis. Current evidence is insufficient to evaluate the efficacy and safety of various HMs. Further studies with improved trial design and reporting, with assessment on cost‐effectiveness, quality of life, and qualitative data are warranted. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Hong Kong</li></country></list><tree><country name="Hong Kong"><noRegion><name sortKey="Chung, Vincent" sort="Chung, Vincent" uniqKey="Chung V" first="Vincent" last="Chung">Vincent Chung</name></noRegion><name sortKey="Bian, Zhaoxiang" sort="Bian, Zhaoxiang" uniqKey="Bian Z" first="Zhaoxiang" last="Bian">Zhaoxiang Bian</name><name sortKey="Gao, Jing" sort="Gao, Jing" uniqKey="Gao J" first="Jing" last="Gao">Jing Gao</name><name sortKey="Kum, Wan Fung" sort="Kum, Wan Fung" uniqKey="Kum W" first="Wan Fung" last="Kum">Wan Fung Kum</name><name sortKey="Leuk Fong, Wai" sort="Leuk Fong, Wai" uniqKey="Leuk Fong W" first="Wai" last="Leuk Fong">Wai Leuk Fong</name><name sortKey="Li, Min" sort="Li, Min" uniqKey="Li M" first="Min" last="Li">Min Li</name><name sortKey="Liu, Liang" sort="Liu, Liang" uniqKey="Liu L" first="Liang" last="Liu">Liang Liu</name><name sortKey="Zhao, Zhongzhen" sort="Zhao, Zhongzhen" uniqKey="Zhao Z" first="Zhongzhen" last="Zhao">Zhongzhen Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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